One of the main challenges in nuclear physics is studying the structure of the atomic nucleus. Recently, it has been shown that high-energy heavy-ion collisions at RHlC and the LHC can complement low-energy experiments. Heavy-ion collisions provide a snapshot of the nuclear distribution at the time of collisions, offering a unique and precise probe of the nuclear structure. In this seminar, l will present the latest studies in the initial conditions using the novel multi-particle correlation technique at relativistic energies. In addition, l will show the paradigm shift of using the access of initial conditions to precisely constrain the quadrupole deformation β2 and triaxial structure of $^{129}$Xe and showcase new opportunities to observe the α-clustering structure of $^{16}$Ο. These latest developments have vast potential in future heavy-ion programs at the LHC. They will be a crucial component in spanning the bridge between the fields of low-energy nuclear physics at the MeV energy scale and high-energy heavy-ion physics at the TeV energy scale.